Technician Position at the European Institute of Oncology and University of Milan, IFOM-IEO-Campus, Milan – Italy
DRUGGABLE EPIGENETIC CIRCUITS IN CANCER ORGANOIDS
The Laboratory of Stem Cell Epigenetics, headed by ERC Investigator Giuseppe Testa, invites applications for a technician position on a highly innovative project that investigates cancer-associated epigenetic dysregulation in primary patient-derived tumor organoids. A major focus of our lab is on disease modelling by integrating uniquely informative cohorts of primary patients’ samples with a cutting-edge combination of cell programming and reprogramming, along with new computational resources for benchmarking differential expression (Germain et al., Nucleic Acids Research 2016). We recently elucidated the Polycomb-dependent dysregulation in transcription factor networks underlying glioblastoma multiforme (Signaroldi, Laise et al., Nature Communications 2016), and defined new benchmarks for the disease-modeling field through the thus far largest cohort of disease-specific, transgene-free iPSC from disorders caused by copy number variations (Adamo et al. Nature Genetics, 2015; News and Views by Urban and Purmann in the same issue).
This project is part of the Epigen Flagship Project of the National Research Council and is aimed at elucidating druggable epigenetic networks underlying ovarian cancer and glioblastoma multiforme, harnessing in vitro patient-derived tumor organoids that we have been spearheading and are now well established in the lab. The candidate will be part of a highly active team of scientists and is expected to master state-of-the-art approaches in molecular and cell biology, including culture of tumor and iPSC-derivatives in both 2D and 3D, preparation of libraries for high-throughput sequencing, and learn/apply a broad range of cutting-edge methods to assist in laboratory practice.
Place of employment and work
The European Institute of Oncology is one of Europe’s leading research institutes in biomedical research. It offers attractive salaries and benefits, an exceptional English-speaking research environment and cutting-edge technological platforms. It is located in the heart of Milan, a vibrant cosmopolitan city.
Undergraduate degree in Molecular Biology, Biotechnology or Biomedicine-related areas, with a proven track record of technical expertise and reliability. We are looking for a highly motivated person to join an interactive, multi-national team at the cutting edge of epigenetics and cancer biology (Signaroldi, Laise et al., Nature Communications 2016; Germain et al., Nucleic Acids Research 2016; Adamo et al. Nature Genetics 2015; News and Views by Urban and Purmann in the same issue; Fragola et al. PLoS Genetics 2013; Burgold et al. Cell Reports 2012; Testa Bioessays, 2011; Campaner et al., Molecular Cell 2011). Operating language of the lab is English.
Giuseppe Testa, MD, PhD, MA
Professor of Molecular Biology, University of Milan
Head, Laboratory of Stem Cell Epigenetics
European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy Tel. +39-02-94375105