2018

 

 

L. Marelli and G. Testa 
Scrutinizing the EU General Data Protection Regulation.
Science  04 May 2018. DOI: 10.1126/science.aar5419 – [PDF]

 

 

 

 

 

 

 

S. Monterisi, P. Lo Riso, K. Russo, G. Bertalot, M. Vecchi, G. Testa, P.P. Di Fiore and F. Bianchi
HOXB7 overexpression in lung cancer is a hallmark of acquired stem-like phenotype
Oncogene. 2018 Mar 26. doi: 10.1038/s41388-018-0229-9. [PDF]

 

 

 

 

 

 

M. Gabriele, A. Lopez Tobon, G. D’Agostino and G. Testa 
The chromatin basis of neurodevelopmental disorders: Rethinking dysfunction along the molecular and temporal axes
Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jan 6. pii: S0278-5846(17)30538-9. doi: 10.1016/j.pnpbp.2017.12.013 – [PDF]

 

 

 

 

2017

 

 

Y. Liu, C. Borel, L. Li, T. Müller, E.G. Williams, P.-L. Germain, M. Buljan, T. Sajic, P.J. Boersema, W. Shao, M. Faini, G. Testa, A. Beyer, S.E. Antonarakis and R. Aebersold
Systematic proteome and proteostasis profiling in human Trisomy 21 fibroblast cells 
Nature Communications 017 Oct 31;8(1):1212. doi: 10.1038/s41467-017-01422-6 – [PDF]

 

 

 

 

 

P.L. Germain, L. Chiapperino and G. Testa
The European politics of animal experimentation: From Victorian Britain to ‘Stop Vivisection’ 
Studies in History and Philosophy of Biological and Biomedical Sciences 2017 (doi: 10.1016/j.shpsc.2017.06.004) – [PDF]

 

 

 

 

 

 

M. Gabriele, A.T. Vulto-van Silfhout, P.L. Germain, A. Vitriolo, R. Kumar, E. Douglas, E. Haan, K. Kosaki, T. Takenouchi, A. Rauch, K. Steindl, E. Frengen, D. Misceo, C.R.J. Pedurupillay, P. Stromme, J.A. Rosenfeld, Y. Shao, W.J. Craigen, C.P. Schaaf, D. Rodriguez-Buritica, L. Farach, J. Friedman, P. Thulin, S.D. McLean, K.M. Nugent, J. Morton, J. Nicholl, J. Andrieux, A. Stray-Pedersen, P. Chambon, S. Patrier, S.A. Lynch, S. Kjaergaard, P.M. Tørring, C. Brasch-Andersen, A. Ronan, A. van Haeringen, P.J. Anderson, Z. Powis, H.G. Brunner, R. Pfundt, J.H.M. Schuurs-Hoeijmakers, B.W.M. van Bon, S. Lelieveld, C. Gilissen, W.M. Nillesen, L.E.L.M. Vissers, J. Gecz, D.A. Koolen, G. Testa*, B.B.A. de Vries*
YY1 Haploinsufficiency Causes an Intellectual Disability Syndrome Featuring Transcriptional and Chromatin Dysfunction 
American Journal of Human Genetics 2017 (doi: 10.1016/j.ajhg.2017.05.006)   *corresponding author – [PDF]

 

 

 

 

 

 

P.L. Germain and G. Testa
Taming Human Genetic Variability: Transcriptomic Meta-Analysis Guides the Experimental Design and Interpretation of iPSC-based Disease Modeling
Stem Cell Reports 2017 (doi:10.1016/j.stemcr.2017.05.012) – [PDF]

 

 

 

 

2016

H. L. Röst, Y. Liu, G. D’Agostino, M. Zanella, P. Navarro, G. Rosenberger, B.C. Collins, L. Gillet, G. Testa, L. Malmström and R. Aebersold 
TRIC: an automated alignment strategy for reproducible protein quantification in targeted proteomics 
Nature Methods 2016 (doi:10.1038/nmeth.3954)

P. L. Germain, A. Vitriolo, A. Adamo, P. Laise, V. Das and G. Testa
RNAontheBENCH: computational and empirical resources for benchmarking RNAseq quantification and differential expression methods
Nucleic Acids Research 2016 (doi: 10.1093/nar/gkw448) – [PDF]

E. Signaroldi, P. Laise, S. Cristofanon, A. Brancaccio, E. Reisoli, S. Atashpaz, M.R. Terreni, C. Doglioni, G. Pruneri, P. Malatesta and G. Testa
Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network 
Nature Communications (Feb 29;7:10753. doi: 10.1038/ncomms10753) – [PDF]

2015

A. Adamo, S. Atashpaz, P.L. Germain, M. Zanella, G. D’Agostino, V. Albertin, J. Chenoweth, L. Micale, C. Fusco, C. Unger, B. Augello, O. Palumbo, B. Hamilton, M. Carella, E. Donti, G. Pruneri, A. Selicorni, E. Biamino, P. Prontera, R. McKay, G. Merla and G. Testa
7q11.23 dosage-dependent dysregulation in human pluripotent stem cells affects transcriptional programs in disease-relevant lineages
Nature Genetics 2015 (doi: 10.1038/ng.3169) – News and Views in the same issue by Urban and Purmann

2014

D.H. Park, S.J. Hong, R.D. Salinas, S.J. Liu, S.W. Sun, J. Sgualdino, G. Testa, M.M. Matzuk, N. Iwamori and D.A. Lim
Activation of Neuronal Gene Expression by the JMJD3 Demethylase Is Required for Postnatal and Adult Brain Neurogenesis
Cell Reports 2014 (doi: 10.1016/j.celrep.2014.07.060) – [PDF]

M. Meloni and G. Testa
Scrutinizing the Epigenetics Revolution
Biosocieties 2014 (doi: 10.1057/biosoc.2014.22) – [PDF]

A. Piunti, A. Rossi, A. Cerutti, M. Albert, S. Jammula, A. Scelfo, L. Cedrone, G. Fragola, L. Olsson, H. Koseki, G. Testa, S. Casola, K. Helin, F. d’Adda di Fagagna and D. Pasini
Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication
Nature Communications 2014 (doi: 10.1038/ncomms4649) – [PDF]

C. Palacios, J. Harris and G. Testa
Multiplex parenting: In Vitro Gametes and the generations to come 
Journal of Medical Ethics 2014 (doi:10.1136/medethics-2013-101810) – [PDF]

2013

M. Caganova, C. Carrisi, F. Mainoldi, F. Zanardi, P.L. Germain, L. George, F. Alberghini, G. Varano, L. Ferrarini, A.K. Talukder, M. Ponzoni, G. Testa, T. Nojima, C. Doglioni, D. Kitamura, K.M. Toellner, I. Su and S. Casola
Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis
Journal of Clinical Investigation 2013 (doi: 10.1172/JCI70626) – [PDF]

L. Schneider, S. Pellegatta, R. Favaro, F. Pisati, P. Roncaglia, G. Testa, S.K. Nicolis, G. Finocchiaro and F. D’Adda di Fagagna
DNA damage in mammalian neural stem cells leads to astrocytic differentiation mediated by BMP2 signaling through JAK-STAT 
Stem Cell Reports (2013) DOI: 10.1016/j.stemcr.2013.06.004

G. Fragola, P.L. Germain, P. Laise, A. Cuomo, A. Blasimme, F. Gross, E. Signaroldi, G. Bucci, C. Sommer, G. Pruneri, G. Mazzarol, T. Bonaldi, G. Mostoslavsky, S. Casola and G. Testa
Cell reprogramming requires silencing of a core subset of Polycomb targets 
PLoS Genetics 9(2), 2013: e1003292

A. Blasimme, B. Schmietow and G. Testa
Reprogramming potentiality: the co-production of stem cell policy and democracy 
American Journal of Bioethics13(1), 2013: 30-2

2012

T. Burgold, N. Voituron, M. Caganova, P.P. Tripathi, C Menuet, B.K. Tusi, F. Spreafico, M. Bévengut, C. Gestreau, S. Buontempo, A. Simeone, L. Kruidenier, G. Natoli, S. Casola, G. Hilaire and G. Testa
The H3K27 demethylase JMJD3 is required for maintenance of the embryonic respiratory neuronal network, neonatal breathing and survival 
Cell Reports 2(5), 2012: 1244-58

L. Austenaa, I. Barozzi, A. Chronowska, A. Termanini, R. Ostuni, F. Stewart, G. Testa and G. Natoli
The histone methyltransferase Wbp7 (Mll4) controls macrophage function through GPI anchor synthesis 
Immunity 36(4), (2012): 572-85

M. Curnutte and G. Testa
Consuming genomes: scientific and social innovation in direct-to-consumer genetic testing New Genetics and Society, (2012)  31:2, 159-181

2011

S. Campaner, F. Spreafico, T. Burgold, M. Doni, U. Rosato, B. Amati, and G. Testa
The methyltransferase Set7/9(Setd7) is dispensable for the p53-mediated DNA damage response 
Molecular Cell 43, 2011; 681-688

G. Testa
The time of timing: How Polycomb proteins regulate neurogenesis 
Bioessays, 2011; 33(7):519-28

G. Boniolo and G. Testa
The Identity of Living Beings, Epigenetics, and the Modesty of Philosophy.
Erkenntnis, 2011; DOI 10.1007/s10670-011-9308-9

C.E. Pasi, A. Dereli-Oz, S. Negrini, M. Friedli, G. Fragola, A. Lombardo, G. Van Houwe, L. Naldini, S. Casola, G. Testa, D. Trono, P.G. Pelicci, and T.D. Halazonetis
Genomic instability in induced stem cells
Cell Death and Differentiation, 2011; 18(5):745-53

2010

G. Testa
Stem Cell Theatrics 
Nature 2010, 465: 1012

2009

G. Testa
What to do with the Grail now that we have it? iPSCs, potentiality, and public policy.
Cell Stem Cell, 2009 5(4):358-9

F. De Santa, N. Vipin, Z. H.Yap; B. K.Tusi, T. Burgold, L. Austenaa, G. Bucci, M. Caganova, S. Notarbartolo, S. Casola, G. Testa, W. Sung, C. Wei and G. Natoli
Jmjd3 contributes to the control of gene expression in LPS activated macrophages 
The EMBO Journal, 2009; 28(21):3341-52

G. Natoli, G. Testa and F. De Santa
The future therapeutic potential of histone demethylases: a critical analysis 
Current Opinion in Drug Discovery and Development 2009; 12(5):607-15

L. Skene, G. Testa, I. Hyun, K. W. Jung, A. McNab, J. Robertson, C. T. Scott, J. H. Solbakk, P. Taylor, L. Zoloth
Ethics Report on Interspecies Somatic Cell Nuclear Transfer Research 
Cell Stem Cell, 2009; 5(1): 27-30

2008

T. Burgold, F. Spreafico, F. De Santa, M. Totaro, E. Prosperini, G. Natoli and G. Testa
The histone H3 lysine 27-specific demethylase Jmjd3 is required for neural commitment 
PloS One 2008 3(8): e3034

J.A. Adjaye, A.G. Byskov, J.B. Cibelli, R. De Maria, S. Minger, M. Sampaolesi, G. Testa, C. Verfaillie, M. Zernicka-Goetz, H. Schöler, M. Boiani, N. Crosetto, C.A. Redi
Pluripotency and differentiation in embryos and stem cells 
Int J Dev Biol 2008 52(7):801-9

G. Testa
Stem cells through stem beliefs: the co-production of biotechnological pluralism 
Science as Culture 2008 17(4): 435-448

2007

F. De Santa, M. Totaro, E. Prosperini, S. Notarbartolo, G. Testa, and G. Natoli
The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing 
Cell 2007 130(6):1083-94

I. Hyun*, P. Taylor*, G. Testa*, B. Dickens, K. W. Jung, A. McNab, J. Robertson, L. Skene and L. Zoloth
Ethical Standards for Human-to-Animal Chimera Experiments in Stem Cell Research
Cell Stem Cell 2007 1(2):159-163 *equal contribution

G. Testa, L. Borghese, J. Steinbeck, and O. Brüstle
Breakdown of the Potentiality Principle and Its Impact on Global Stem Cell Research
Cell Stem Cell 2007 1(2):153-156

J. Scholten, K. Hartmann, A. Gerbaulet, T. Krieg, W. Müller, G. Testa, and A. Roers
Mast cell-specific Cre/loxP-mediated recombination in vivo 
Transgenic Res. Epub 2007 Oct 31 (2008 (2):307-15)

2006

G. Testa
Nuclear Transfer: an Example of Responsive Epistemologies 
Preprint 310 of the Proceedings of the Max Planck Institute for the History of Science 2006 pp. 205-214

2005

G. Testa and J. Harris
Ethics and synthetic gametes
Bioethics, 2005; 19: 146-166

G. Testa and J. Harris
Ethical aspects of ES cell-derived gametes
Science, 2004; 305:1719

G. Testa and J. Harris
The ethics of deriving gametes from ES cells, response to A. Lippman and S.A. Newman
Science, 2005;307: 515c-517c

2004

G. Testa, J. Schaft, F.v.d. Hoeven, S. Glaser, Y. Zhang, T. Hermann, W. Stremmel and A. F. Stewart
A reliable lacZ expression reporter cassette for multipurpose, knock-out-first, alleles 
Genesis, 2004, 38(3):151-8

G. Testa, K. Vintersten, Y. Zhang, V. Benes, J.P.P. Muyrers and A. F. Stewart
BAC Engineering for the generation of ES cell-targeting constructs and mouse transgenes Methods Mol Biol. 2004; 256:141-58

K. Vintersten, G. Testa, A. F. Stewart.
Microinjection of BAC DNA into the pronucei of fertilised mouse oocytes 
Methods Mol Biol. 2004; 256: 141-58

J.P.P. Muyrers, Y. Zhang, V. Benes, J.M.J. Rientjes, G. Testa and A. F. Stewart
ET recombination: DNA engineering using homologous recombination in E. coli
Methods Mol Biol. 2004; 256: 107-22

2003

G. Testa, Y. Zhang, K. Vintersten, V. Benes, I. Chambers, W. W. M. Pim Pijnappel, A. J.H. Smith, A. A. Smith and A. F. Stewart
Engineering the mouse genome with bacterial artificial chromosomes to create multipurpose alleles 
Nature Biotechnology, 2003; 21(4): 443-7

2001

T. Schell, G. Testa, S. Castagnetti, B. Rutz, M. Hannus and F. Frischknecht
Neuroscience from different angles. Student symposium: From genes to thoughts
EMBO Reports 2001 Jun; 2(6):471-5

2000

G. Testa and A. F. Stewart
Creating a transloxation: engineering interchromosomal translocations in the mouse 
EMBO Reports, 2000 Aug; 1(2):120-1

Y. Zhang, J. P. P. Muyrers, G. Testa and A. F. Stewart
DNA cloning by homologous recombination in Escherichia coli.
Nature Biotechnology 2000 Dec; 18(12):1314-7

J. P. P. Muyrers, Y. Zhang, V. Benes, G. Testa, W. Ansorge and A. F. Stewart
Point mutation of bacterial artificial chromosomes by ET recombination.
EMBO Reports 2000 Sep; 1(3):239-43

1999

J. P. P. Muyrers, Y. Zhang, G. Testa and A. F. Stewart
Rapid modification of bacterial artificial chromosomes by ET-recombination
Nucleic Acid Research, 1999 Mar 15; 27(6): 1555-1557

1995

G. Nocentini, S. Ronchetti, A. Bartoli, G. Testa, F. D’Adamio, C. Riccardi and G. Migliorati
TCRi: an alternatively sliced product of the T cell receptor zeta gene 
European Journal of Immunology 1995 25: 1405-1409

 

 

Peer-reviewed books and book chapters

G. Testa and E. Meshorer (Eds)
Stem Cell Epigenetics, Series: Translational Epigenetics
Academic Press, Elsevier, forthcoming in 2018

G. Testa
La medicina di precisione tra frontiere scientifiche e sfide di cittadinanza
in ‘Europa: un’utopia in costruzione’, Vol. II, Enciclopedia Italiana Treccani forthcoming in 2018

L. Marelli and G. Testa
Having a Structuring Effect on Europe: The Innovative Medicines Initiative and the Construction of the European Health Bioeconomy
in V. Pavone and J. Goven (Eds.) ‘Bioeconomies: Life, Technology, and Capital in the 21st Century’ Palgrave 2017

L. Chiapperino and G. Testa
The Epigenomic Self in Personalised Medicine: between Responsibility and Empowerment
in M. Meloni, S. Williams, P. Martin (Eds.) ‘Biosocial Matters: Rethinking Sociology-Biology Relations in the Twenty-First Century’, Wiley-Blackwell 2016

I.Galasso and G. Testa
Medicina di Precisione: rifare il destino tra sfida e utopia
in M. Monti, S. Garagna, G. Milano and C.A. Redi (Eds.)
Medicina di precisione. Un esercizio di cittadinanza scientifica e democrazia cognitiva
Pavia Collegio Ghislieri Ibis Edizioni 2015

G. Testa
Democracies of stemness: stem cell technologies from generation to regeneration 
in F. Calegari and C. Waskow (Eds.) ‘Stem Cells. From Basic Research to Therapy’, CRC Press (2014)

G. Boniolo and G. Testa
Legittimità morale, cellule staminali embrionali umane ed embrioni umani 
in G. Boniolo and P. Maugeri (Eds.) Etica alle frontiere della biomedicina. Per una cittadinanza consapevole. Mondadori Università, 2014

G. Testa and A. Maturo
Medicina rigenerativa ed embrioni 
in G. Remuzzi and A. Maturo (Eds.) ‘Ci curano o ci curiamo? Il malato tra crisi economica e responsabilità individuale’, Franco Angeli, Milano 2013

G. Testa
Stem cells and the structuring of the Italian biopolity 
in H. R. Rheinberger and R. Mazzolini (Eds.) ‘Different routes to stem cell research: Germany and Italy’, Il Mulino (Bologna) and Duncker & Humblot (Berlin)(2012)

G. Testa
More Than Just a Nucleus: Cloning and the Alignment of Scientific and Political Rationalities
in Sheila Jasanoff (Ed.) ´Reframing Rights: Bioconstitutionalism in the Genetic Age´, 2011 MIT Press, pp. 86-104

H. Nowotny and G. Testa
Naked Genes. Reinventing the Human in the Molecular Age 
2011 MIT Press (originally appeared as ‘Die gläsernen Gene. Die Erfindung des Individuums im molekularen Zeitalter’, 2009 Suhrkamp Verlag; Italian translation ‘Geni a nudo. Ripensare l’uomo nel XXI secolo’, Codice Edizioni 2012; Russian translation forthcoming) Reviewed in Nature, The Financial Times, Die Zeit, Der Spiegel, Il Corriere della Sera, BBC Science

G. Testa
Cloning as Mirror
in Cristoph Zollikofer (Ed.) ´Klon statt Person´, 2011 Hochschulverlag AG an der ETH Zuerich, pp. 45-50

G. Testa
Le scienze della vita. Verso nuove antropogenesi?
in Antonio Pavan and Emanuela Magno (Eds.) ´Antropogenesi. Ricerche sull’origine e lo sviluppo del fenomeno umano´ 2010, Il Mulino

G. Boniolo, G. Gatti, G. Pelicci and G. Testa
Cellule staminali. La base scientifica, le future terapie. La riflessione etica al di là dello slogan ideologico. Le risposte della scienza. 
Quaderno 11 Libertà di sapere libertà di scegliere Fondazione Umberto Veronesi per il progresso delle scienze

G. Testa and S. Giaimo
Il concetto di gene
in Giovanni Boniolo e Stefano Giaimo (Eds.) ´Filosofia e Scienze della Vita. Un´analisi dei fondamenti della biologia e della biomedicina´ 2008 Bruno Mondadori

G. Testa and A. Minelli
Vincoli ed epigenesi
in Giovanni Boniolo e Stefano Giaimo (Eds.) ´Filosofia e Scienze della Vita. Un´analisi dei fondamenti delal biologia e della biomedicina´ 2008 Bruno Mondadori

G. Testa
Che cos’è un clone? Practiche e significato delle biotecnologie rosse in un mondo globale
in Massimiano Bucchi and Federico Neresini (Eds.) ´Cellule e Cittadini´ (Cells and citizens), 2006 Sironi Editore

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